Argentina defender Marcos Rojo dislocated his shoulder in Manchester United's 1-0 defeat at Manchester City on Sunday, their manager Louis van Gaal confirmed.
Manchester City beat bottom club Sheffield United 1-0 to move three points clear of Manchester United who were held to a goalless draw at Arsenal in the Premier League on Saturday.
The Premier League leaders preserved their 11-point lead with a 4-1 victory over Crystal Palace.
Following is a match by match look at the English Premier League's weekend fixtures
The two players, who are injured, will miss Manchester United's Champions League clash against AC Milan.
Realistically, the Foxes, who beat Chelsea in the FA Cup final last Saturday, need to win and hope one of their rivals slip up.
A round-up Wednesday's football news on and off the field.
The club anthem Blue is the Colour resounded around a joyful Stamford Bridge and champagne flowed as Chelsea clinched their first Premier League title for five years with a typically stubborn 1-0 victory over Crystal Palace on Sunday.
The 22-year-old has signed on an eight-and-a-half-year contract in deal worth 100 million euros ($108 million).
Manchester United midfielder Michael Carrick will miss the final three games of the Premier League season with a calf problem, manager Louis van Gaal said on Friday.
Match-by-match facts and statistics ahead of the Premier League
Joint-leaders Tottenham Hotspur and Liverpool both dropped points on a busy day of English Premier League action as Leicester City and Southampton narrowed the gap in what is shaping up to be one of the most open title races for years.
The victory takes Pep Guardiola's side into provisional second spot
Images from the English Premier League matches played on Saturday.
The Arsenal defender will be sidelined for two weeks after sustaining an ankle injury.
Liverpool need five points to be sure of their first English league crown in three decades and dethrone City, who have won the title in the last two seasons.
Sergio Aguero scored a hat-trick as free-scoring Manchester City climbed to the top of the Premier League with an irresistible 6-0 victory against Watford on Saturday.
Tottenham Hotspur and Newcastle United both sealed comeback victories to boost their European qualification hopes.
The British Govt amended the Special License enabling Chelsea FC to sell tickets to select competitions to fans
The Premier League kicked off in unique fashion on Saturday as an own goal by Tottenham Hotspur's Kyle Walker gave Manchester United a 1-0 victory in an undistinguished season opener at Old Trafford.
Everton moved up to third place in the Premier League despite being held to a 1-1 draw by Crystal Palace as Belgium strikers Christian Benteke and Romelu Lukaku both got on the scoresheet in a battling encounter on Friday.
IMAGES from the Premier League matches played on Wednesday.
Chelsea beat Norwich City 3-1 as title rivals Manchester United stumbled to a 0-0 draw against a 10-man Crystal Palace.
Images from the football matches played on Tuesday.
Liverpool moved into the top five of the English Premier League with a 2-1 victory at relegation-threatened Norwich City.
Newcastle United striker Papiss Cisse has been charged with violent conduct, the FA said in a statement on Monday referring to an incident in the Premier League match against Everton.
The match lived up to its billing right from the start
Goals from Freddie Hinds, Bobby Reid and Niclas Eliasson put the visitors through to the third round. Watford finished with 10 men after Jose Holebas was sent off.
Chelsea exploited Manchester City's decision to field a weakened team by romping to a 5-1 win in the FA Cup fifth round on Sunday as they joined London rivals West Ham United and Crystal Palace in the quarter-finals.
Leicester City manager Claudio Ranieri has asked for a change in mentality to revive the club's Premier League campaign which is in stark contrast to their impressive Champions League form.
IMAGES from the Premier League matches played on Saturday.
City were not at their all-action best early on as Burnley looked comfortable at the back, but the game turned on a penalty decision that incensed the visitors when Bernardo Silva was adjudged to have been brought down by Burnley goalkeeper Nick Pope just before the half hour.
A summary of Tuesday's action in the Premier League.
Chelsea kept alive their remote Premier League title chances with a 2-0 win over London rivals Tottenham Hotspur on Sunday, set on their way by an exquisite strike from Hakim Ziyech which was quickly followed up by a Thiago Silva header.
A match by match look at this weekend's English Premier League fixtures.
IMAGES from the English Premier League matches played on Saturday.
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